End-Stage Renal Disease :: Health, Diseases, Hemodialysis Patients

IntroductionPatients with End-Stage Renal complaint (ESRD) had higher anemia rate than general creation (1). Several studies considered incendiary markers as predictors of outcome in patients with ESRD and in one of them which was performed on 25000 HD patients, neutrophil count combined with low lymphocyte count were independent predictor of outcome in hemodialysis patients (2). In some of other studies marvelous take of C- thermolabile protein was accounted for higher fatality rate rate in HD patients (3). In a European study, CRP were presented as one of the uremic syndrome futures and 50% of patients have CRP take 8mg/l and 75% of them had CRP level 3.4mg/l (3). Anemia related add-on serum level of pro-inflammatory factors with poor treatment outcomes in HD patients (4). in that location is relationship between anemia, inflammation and oxidative stress level. Serum level of hemoglobin was increased during 2-3 days after inflammatory response to infection. inflaming als o active macrophages and remove old erythrocytes from the serum of HD patients (5). According to findings of preceding studies, ESRD is one of the states that increase pro-inflammatory cytokines and in some of them interleukins (IL) 1, 4 and 6 and tumor necrosis factor (TNF) were 8-10 times higher than general population (6). Statine agents can reduce serum level of CRP in HD patients and decline their affect to Epoetin for management of anemia (7). Serum CRP level more than 5-10 mg/l is associated with cardiovascular events and statine agents due to reduce CRP level might decline mortality of HD patients and improve their cardiovascular outcome. Measurement of Serum level of C reactive protein (CRP) in hemodialysis (HD) patients with anemia and their response to lovastatin is aim of our study. corporeal and methodsOne hundred fifty hemodialysis patients in Imam Khomeini and Amiralam hospital during 2004 were participated in our randomized clinical trial. Hemodialysis pati ents had leash sessions per week hemodialysis plan with Polysulphone and Hemophane dialysis filters and bicarbonate as dialysis solution. Our study was approved in good committee of Tehran medical university and informed consent was obtained from each patient. Our cellular inclusion criteriaOur inclusion criterias were more than hemodialysis patients with six months hemodialysis and Hs-CRP higher than 10 mg per liter, without tumors, chronic respiratory disorders, iron deficiency anemia, hypothyroidism, diabetic tail ulcer, total cholesterol more than 200 mg/dl, abnormal colorful tests, immunosuppressive, beta blocker and statine usage, and active infection in recent three months.